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Cas No. 459789-99-2 Obeticholic Acid

Cas No. 459789-99-2 Obeticholic Acid

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Chemical Name: Obeticholic Acid
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459789-99-2
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Molecular Type: C26H44O4
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Obeycholic acid is a novel derivative of chenodeoxycholic acid (CDCA) in human primary bile acids, and is a natural ligand for the farnesyl ester derivative X receptor (FXR). Obecocholic acid is a fanitol X receptor agonist that indirectly inhibits the gene expression of cytochrome 7A1 (CYP7A1) by activating the fanitol X receptor. Due to CYP7A1 being a rate limiting enzyme for bile acid biosynthesis, obycholic acid can inhibit bile acid synthesis and be used for the treatment of primary biliary cirrhosis and non-alcoholic fatty liver disease. Obeycholic acid is the first drug developed in 20 years to treat cholestatic liver disease, targeting patients with insufficient response or intolerance to ursodeoxycholic acid.

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